A member asked:

I think i was exposed to hsv 2 and took an hsv 2 igg test 3 weeks later, the test came back "equivocal". did i test too early or would my titers have been well into the positive at this point? range for equivocal is .90 - 1.09, my result was 0.91?

2 doctors weighed in across 2 answers

The IgG test detects chronic antibodies to HSV, not acute ones. You should have had an IgM test. 0.91 is the absolute lower limit of equivocal, meaning you probably do not have any longterm antibodies to HSV, but it doesn't give you any information about recent exposure. Get an IgM test -- and because the IgG was not definitive, I would repeat that as well.

Answered 12/14/2021

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Dr. Hunter Handsfield answered

Specializes in Infectious Disease

It takes 12 weeks for conclusive HSV2 antibody testing. With no symptoms of a new HSV infection, most likely this has nothing to do with your recent sexual exposure, and most people with equivocal results are not infected. However, you could be seroconverting. Have another IgG test at 6 weeks, by which time 80% of newly infected persons are positve; and again at 12 weeks. IgM tests are unreliable

Answered 12/15/2021

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