Is it safe to take st john's wort with wellbutrin?

There are possible interactions in different ways, St John’ s wort may increase the risk for side effects for Wellbutrin and/or make the drug less efficient. Best is to let your prescriber know that can make a recommendation in proper context.

Unclear as to rationale to add an OTC emotional agent to Wellbutrin, an effective antidepressant. Would anticipate an increase in adverse events, with little positive benefit. Would strongly urge a discussion with your doctor prior to proceeding in proposed direction.