A member asked:

I have been on varius ppi medication for almost a decade. i am worried about the continue use, and if they cause cancer? i have gerd, even had surgery for it(linx device), but cannot get off ppi or i will have my shortness of breath come/throat burn?

3 doctors weighed in across 2 answers
Dr. Silviu Pasniciuc answered

Specializes in Internal Medicine

More and more described, PPI’s are becoming increasingly hard to wean, specifically in patients with severe hyperacidity/ reflux symptoms. They are not known to be linked to increased risk for cancer though, but rather a variety of chronic conditions related to chronic acid suppression. Your best reference remains your gastroenterologist who might be able to taper slowly doses/ rotate PPI’s.

Answered 5/19/2021

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You are correct in being concerned about prolonged taking of ppi's. Concerns include kidney disease, dementia,B12 deficiency, susceptibility to fractures & C diff intestinal infections. Consider switching to a different class of acid blockers such as famotidine. which is better tolerated in younger versus elderly people after long-term use. Your gastroenterologist can also advise you.

Answered 5/20/2021

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