I m i taking venlafaxine hcl xr37.5mg for 4 years . is it safe to take venlafaxine for long time?

No medicine is safe to be taken without clear goals and understanding of what is being treated and a clear risk-benefit ratio discussion. Best to answer your question would be your current prescriber who diagnosed the condition you are being treated for in the context of your current symptoms.

Yes: Unfortunately, it’s impossible to go through the whole list of venlafaxine’s side effects or the way it interacts together with other drugs, but for long-term treatment, one concern is that venlafaxine may raise a person’s blood pressure. Over time, that may be damaging to a person’s blood vessels, so it’s important for a person to make sure that her blood pressure is well controlled.