Will long-term use of lactulose cause sibo,pneumatosis cystoides intestinalis?

Colonic bacteria metabolize lactulose into monosaccharide, fatty acids, hydrogen, methane. Lactulose is not administered chronically, mainly used to prevent Liver encephalopathy. In prolonged use lactulose can change the gut flora and give rise to small intestinal bacterial overgrowth. Large amount of gas produced can cause pnematosis. Cystoidis is when gas is all around the colon. Hope it help