Does taking multivitamins pill supplement that include zinc, calcium and magnesium negate the effects of long term ppi use that leads to increase in chance of or the causing of osteoporosis and increased chance of bone fracture?

No but it does deplete your funds that be spent can be used for healthier was. I recommend the DASH DIET which is high in Calcium, magnesium, tends to lower BP even in those with a normal bp, Lowers lipids, improves glucose and meets all the recommendations of the Cancer gurus to prevent many cancers. Go to uptodate.com and read more. Good luck.