My wife has this headache since wednesday evening and it seems to be getting worse as the ibupain she is taking doesn't help take it away. she also complained about a pain going down her neck a few minutes ago?

ER can evaluate now: Most people have a headache at some time, such as from colds and flus, lack of sleep, too much driving, long hours on the computer, stress at work, etc... Several over-the-counter options include Tylenol, Motrin, Aleve, Excedrin, etc... However, a "worst ever headache" or a really severe headache should be seen in the ER right away, as a very serious problem can be the cause.