My ankles are incredibly itchy lately, what could be the cause and what is the possible cure ?

Some basics: Have you looked at the area ? Is there a shoe you wore or sweated into that could have triggered the issue as a local response? Did you walk through an area with insects that may have bit you? Have you applied any cream/lotion that you reacted to ? Treatment if any would depend on the cause. A good wash with cold water may give some relief as would a mild cortisone cream.