Some resistance : https://www.cdc.gov/std/tg2015/syphilis.htm Penicillin G, administered parenterally, is the preferred drug for treating persons in all stages of syphilis. Azithromycin as a single 2-g oral dose has been effective for treating primary and secondary syphilis in some populations. However, T. pallidum chromosomal mutations are associated with azithromycin failures.
Answered 2/7/2019
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