Opioid allergies: Hi, Molecularly, opioids are classified into three groups: naturally occurring, semi-synthetic, and full synthetic. Tramadol falls into the fully synthetic group. If you have a reaction to natural and semi-synthetics, theoretically you should be ok taking tramadol, however if you have life threatening reactions, your doctor may not be comfortable taking the risk to prescribe it. Hope this helps
Answered 3/15/2022
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