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A 32-year-old female asked:

does prozac (fluoxetine) cause ultram to work better? i saw that prozac (fluoxetine) increases opiod receptors in brain. have back pain, osteoarthritis pain, foot nerve damage.

5 doctor answers15 doctors weighed in
Dr. Ahmad M Hadied
Orthopedic Surgery 49 years experience
NO,There is a : Potential interaction between Prozac (fluoxetine) and ultram .There is a risk of developing serotonin syndrome when the two medications are taken together. Serotonin syndrome can be serious and even life threatening. It is the result of high levels of serotonin in the body. Serotonin syndrome is characterized by having at least three of these listed symptoms: tremor, shivering, agitation, diaphoresis fever.
Dr. John Moranville
Psychiatry 36 years experience
Unlikely: No evidence i know of that and there are significant interactions. Though interactions are the same there is evidence that Cymbalta (duloxetine) may help with chronic pain. Talk to your doctor about all the medications you are on and he/she can help you weigh the benefit vs risk of such combinations.
Dr. Richard Williams
Pharmacy 18 years experience
Maybe the wrong cate: Often, antidepressants of a certain class can be used in combination with opioids for neuropathic pain. The class includes drugs like cmybalta. Check with your physician
Dr. Vikas Duvvuri
Psychiatry 16 years experience
See below: Depression worsens the experience of pain. Prozac (fluoxetine) reduces depression and ultram reduces pain. However, there are better options if the goal is to treat depression and especially neuropathic pain as the other answers suggest.
Dr. Douglas Bey
Psychiatry 57 years experience
Both up serotonin: There is a precaution about using both as it could lead to a serotonin syndrome--your question is interesting both raise serotonin--do you think they r helping?

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Last updated Aug 8, 2016

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