How do genetics factor in to glaucoma that isn't successfully controlled. does it mean that resistance to treatment for glaucoma is hereditary?

No: Many factors play into successful glaucoma control. Age at diagnosis, severity of disease at diagnosis. Type of glaucoma diagnosed: pseudoexfoliative, pigmentary, narrow angle , genetic inheritence--axenfelds syndrome, etc many types of treatments are available today. If you are having difficulty with glaucoma control seek a consultation at a academic eye center's glaucoma department.

Probably: Research is elucidating much information on how genetics play a pathophysiologic role in glaucoma. It is true that those individuals affected by the most common form of glaucoma (poag) have been found to have mutations in several genes, including myocilin, optineurin, and cyp1b1. Some of the defective proteins formed by these mutants may have more negative influence on how responsive treatment is.