If a person has overlap myeloproliferative-myelodysplastic disorder which is causing an elevated wbc and a very high (and increasingly high) crp, could antibiotics bring down the crp even if there is no infection?

No: CRP is rather a nonspecific marker for inflammation and other disorders as blood diseases, myeloproliferative disorder is one of those diseases. Antibiotics won't help, treating the original problem is the answer, elevated CRP isn't the problem, wish you all the best

NO: Antibiotics have no effect without an existing superimposed infection! Hope this is helpful! Dr Z