I have started taking prempro again after a year. the hot flashes and sweats were horrible and so went back to prempro. i started to retain fluid.

Side effect: this is most likely side effect of hormonal therapy. I suggest calling your gYN and get evaluated for the fluid retention.

Prempro: can cause fluid retention. You might benefit from a lower dose of Prempro. It may be a difficult balance to get the beneficial effects of controlling hot flashes and sweats without the adverse effect of fluid retention.