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A member asked:

I been on seroquel 600mg for more than 4 years, now my doctor wants to prescribe me methadone for pain and other issues is this safe?

A doctor has provided 1 answer
Dr. Stephen Watson answered

Specializes in Pain Management

QT prolongation: I have not prescribed a lot of Seroquel but that is a moderate dose. I would be concerned, personally, about adding methadone. That narcotic by itself is a very good drug. Higher doses known to cause significant heart rhythm disturbances or worse. Small to moderate dose of methadone might be alright but I would be concerned. Have to depend on your doctor-specifically ask vs safety/interaction

Answered 3/20/2019

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