Interaction possible: Both Zofran (ondansetron) and Zoloft (sertraline) increase QTc interval of the cardiogram, and both can increase the serotonin effect. These effects may be problematic for some people. Wellbutrin (bupropion) and Zoloft can increase each others' levels which may be problematic. Best to discuss with your prescriber, especially if you experience significant side effects. Best regards for relief.
Answered 7/9/2016
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