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A 28-year-old male asked:

I am taking benadryl (diphenhydramine) with minimal side effects only light sedation. going to try hydroxyzine. will i get more side effects than benadryl (diphenhydramine)?

2 doctor answers2 doctors weighed in
Dr. Shadia Constantine
Specializes in Internal Medicine
Maybe...: I only found one head to head comparison and the study was small. Seems that hydroxyzine has more "anti-itch" effect. The side effects were similar. In a non-scientific website surveying users, seems that Hydroxyzine had more reported side effects. I would like to know what kind of effect are you looking for. They both have some similar and different actions.
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Dr. Catherine Spratt turner
Family Medicine 35 years experience
Hydroxzine: It depends upon the dose you were taking. Benedryl is a antihistamine that is usually very sedating. If you were on a small dose of benedryl and now u You are going on a large dose of Hydroxzine you may have more sedation.
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Oct 10, 2017

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