A 39-year-old female asked:
Is it safer to take benadryl (diphenhydramine) or hydroxyzine while taking tramadol 75-100mg?
1 doctor answer • 5 doctors weighed in
Pediatrics 24 years experience
Using benadryl together with tramadol may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Using hydroxyzine together with tramadol can cause additive central nervous system depression and can lead to serious side effects including respiratory distress. The Benadryl is less problematic than the Hydroxyzine.
Reviewed Apr 03, 2021
Last updated Apr 3, 2021
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