A 45-year-old female asked:
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Is it safer to take Benadryl (diphenhydramine) or hydroxyzine while taking tramadol 75-100mg?

1 doctor answer
Dr. John Chiu
Dr. John Chiu answered
56 years experience in Allergy and Immunology
Neither is better: Since both of the drugs have sedating effects, the choice would depend on which sedates you less or more (depending on your goal). Neither interacts with tramadol otherwise.
Answered on Jul 13, 2014

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Related questions:

A member asked:
Dr. Atul Singh
27 years experience in Nephrology and Dialysis
Sleepy: Both medications can make you sleepy, be careful, don't drive or operate any machinery while on these. But they can be taken.
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A 32-year-old female asked:
Dr. John Chiu
Dr. John Chiu answered
56 years experience in Allergy and Immunology
Yes: Both antihistamines have sedating properties and Benadryl is present in most OTC sleep aids under different names. However they don't work for everyo ... Read More
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A 47-year-old female asked:
Dr. John Chiu
Dr. John Chiu answered
56 years experience in Allergy and Immunology
Unrelated: Although they can both cause drowsiness, they are not allergenically or chemically related.
A 32-year-old male asked:
Dr. Al Hegab
Dr. Al Hegab answered
39 years experience in Allergy and Immunology
May be: Side effects are unpredictable, hydroxyzine is rather a stronger antihistamine than Benadryl, (diphenhydramine) you don't want to combine them unless ... Read More
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1 thank

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