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A member asked:
Mcv low rdw, tsat, lymph, platelets, high gran/wbc recurring fever and increased kappa lambda chains with normal ratio. can this by due to malaria?
A doctor has provided 1 answer
Increased kappa lambda chains: Antibodies are produced by B lymphocytes, each expressing only one class of light chain. Once set, light chain class remains fixed for the life of the B lymphocyte. In a healthy individual, the total kappa to lambda ratio is roughly 3:1 in serum (measuring intact whole antibodies) or 1:1.5 if measuring free light chains, with a highly divergent ratio indicative of The exact normal ratio of kappa
Answered 5/18/2016
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