Usually Once: The hbv vaccine is a series of 3-4 shots over a 6 months time period. At least 90% of people will develop immunity following that series. A portion of remaining people will respond to a second series. There is a very small group who do not develop immunity from vaccination. Booster shots are no longer recommended for people with normal immune status who have been fully vaccinated.
Answered 4/9/2013
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