How does osteosarcoma affect the skeletal system?

Spreading: by spreading the cancer first to the rest of the limb, and later it becomes systemic all over

Varies: Osteosarcoma is a cancer that arises from the bone itself. It can grow locally and can symptoms, and it can potentially metastasize throughout the body. Treatment varies and is based in part on the staging of the cancer; but can involve surgery, radiation, and chemotherapy.