My hands between my fingers itch ferociously turn red and swell but only at night or while i'm sleeping. what could it be?

Soap? Fleas?: Hard to say. Use only unscented soaps, detergents, lotions, aerosols, room sprays. You may be reacting to them. Use fragrance-free detergents for sensitive skin and avoid fabric softeners (which don't really soften clothes, just add another irritating chemical). Could you have fleas, or other pests, in your house? If not, and you don't get better, see your doc to find out what is going on.