Swelling and pain in right thumb ip joint with fatigue. have had this occasionally before but usually goes away. could it be ra?

Arthritis, probably: this type and location of pain is quite typical of arthritis, particularly osteoarthritis. You are more likely at 63 to have this type than rheumatoid type, and thumb is a very common location in older women. Try Tylenol (acetaminophen) and heat. See a clinician about the fatigue and try to get off the ofloxacin...why should you need two antibiotics? The "oxacins" can cause tendon issues which you don't need.