Morning stiffness and swelling both wrists for several hours. redness, pain, warmth in several joints, worse with activity. blood work negative. ra?

Could be: Other possibilities include infections, such as Lyme disease. Was your C-reactive protein elevated?

Arthritis. 3 options: Osteoarthritis: blood work negative, possible family members with similar findings Autoimmune arthritis: Rheumatoid, psoriatic or other. Blood work frequently negative. Infectious/crystal-induced arthritis: Lyme disease, viral infection, syphilis, gout, pseudogout. See a rheumatologist who will sort these options out for you.