Does zofran (ondansetron) stop nausea from panic attacks?

It may help: but you need to calm down. Your anxiety need to get better, before your nausea will get better.

It can: yes, the medication can short-circuit nausea and vomiting due to panic attacks. Better solution might be to reduce the panic attacks themselves either entirely or by intensity and frequency. Then, Zofran (ondansetron) becomes a non-issue.