A member asked:

Can i take zofran (ondansetron) for nausea if i take 10mg prozac once a day? are there any interactions?

6 doctors weighed in across 3 answers
Dr. Olav Jaren answered

Specializes in Neurology

Sometimes there is an interaction, but generally, these can be safely used together. Zofran can cause sleepiness, this is the primary side effect to be aware of.

Answered Sep 14, 2018


Dr. Charles Turck answered

Specializes in Pharmacology

Taking the two medications together occasionally is not usually a problem. It is important that they have both been prescribed and that the doctor who prescribed them knows that you are on them both. If you happen to have a heart condition or history of arrhythmias, you will want to be sure to have your full medication regimen reviewed by a physician or pharmacist before use together.

Answered Oct 12, 2017


Dr. Erin Robertson answered

Specializes in General Practice

Interaction Checker: both meds increase QTc interval. "Possible serious or life-threatening interaction. Monitor closely. Use alternatives if available...ECG monitoring recommended [especially] with electrolyte abnormalities, congestive heart failure, or bradyarrrythmias (slow heart rate). Either increases toxicity of other by [impacting] serotonin levels." Please discuss this with prescribers.

Answered May 23, 2017



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