COMMENTS: Of the listed three, Cymbalta causes nausea in 40%, and is the least likely to cause weight gain. Savella (milnacipran) may be of value in pain syndromes such as fibromyalgia, and seems to also be less troublesome. A possible alternative to gabapentin could be Grailise or Horizant, and due to duration of action may be also less weight gain. The meds cause appetite change, so less caloric intake can prevent.
Answered 7/15/2020
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