A member asked:

Can decreasing hepatic gluconeogenesis treat diabetes type 1 and type 2?

A doctor has provided 1 answer
Dr. Milton Alvis, jr answered

Specializes in Preventive Medicine

Yes, for Type 2 in: which hepatic gluconeogenesis ↑es BG after eating: the GlP-1 analogues ↓ secretion of glucagon after eating (most powerful) along with some ↑ in Beta cell function, etc., metformin by ↓ing gluconeogenesis within the liver (less powerful). For Type 1, suppressing gluconeogenesis dangerous; blocks internal protection for insulin induced hypoglycemia. https://goo.gl/t7WtbR is very helpful for both!

Answered 12/28/2015

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