What can happen to someone who uses oxymetazoline nasal drops for years and years without stopping?

Oxymetazoline use: it stops having an effect and can actually make things worse - Oxymetazoline or AFRIN (oxymetazoline) - works well for maybe 1-2 days but then can cause the same symptoms it was being used to treat. I would STOP using it - allow your body to flush it out of its system see http://en.wikipedia.org/wiki/Oxymetazoline good luck