A member asked:

Positive ana 1:80 speckeled, p.o.t.s syndrome, fat malabsorption, would this link to scelerderma, i cannot think of any other issue, :-( that connects?

4 doctors weighed in across 2 answers
Dr. Richard Jimenez answered

Specializes in Rheumatology

May not be one cause: Autoimmune diseases can cause all your symptoms, however, a low positive ANA is non specific. Fat malabsoprtion can be seen in pancreatic disease with sjogren's & +ana. Also, hypermobility syndrome which is associated with autonomic dysfunction, mast cell activation disorder, food allergies, and folate (folic acid) metabolism issues also presents in young females, unrelated to autoimmune disese. Get a workup.

Answered 3/13/2015

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I doubt it: In the absence of raynaud's / skin changes prior to malabsorption, i'd be surprised if this was scleroderma. ANA especially at low-titer 1:80 very likely means nothing. Other causes of malabsorption are fairly common & can be worked up. Mild orthostatic tachycardia is probably more common than we think. I appreciate your research but i'd keep looking for answers & staying optimistic.

Answered 6/10/2014

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