A member asked:

Is ranitidine a ppi?

3 doctors weighed in across 3 answers
Dr. Keshav Narain answered

Specializes in Retinal Surgery

No, H2 blocker: A ppi refers to proton pump inhibitor class of medication. Ranitidine is an h2 blocker and acts via a different mechanism.

Answered 5/22/2019

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No: It is a medication which blocks histamine. Histamine can stimulate the acid producing cells in the stomach to secrete acid. Ppi refers to a different way to decrease stomach acid secretion. They block the cells ability to actually move hydrogen ions out of the cell into the lumen if the stomach.

Answered 5/22/2019

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Dr. Ralph Morgan Lewis answered

Specializes in Family Medicine

No, it's a blocker: Of the histamine-2 receptor, which stimulates gastric acid secretion. Ppi's work by a different mechanism: they irreversibly block the hydrogen/potassium Adenosine triphosphatase enzyme system (the gastric proton pump) of the gastric parietal cells, which secrete acid. Ppi's tend to be stronger inhibitors of acid secretion.

Answered 7/24/2019

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