What to do if the new bottle of oxycodone is less effective?

Oxycodone: All drugs, trade name or generic, must meet strictly regulated requirements of potency. As such, i would not expect significant deviations in effect from different batches of drug, but would consider possible opioid tolerance development if you have been taking the drug for a prolonged period of time. I would recommend follow-up with the prescribing physician to seek out possible causes.

Discuss with Pharm: It is possible that the medication you are getting has been changed to a generic form that might not be as effective. This can be confirmed by talking to the pharmacist. It also possible that you developing opiate hyperalgesia. That is to say that the original dose of narcotic is no longer as effective. Here you will need to talk to your doctor about other medications or treatments.