Day or so: Cortizone (hydrocortisone) cream like all corticosteroids to become effective needs to be transported into the cytoplasm of the cell where it binds the steroid receptor. This is transported into nucleus and binds to another receptor. This affects mrna which then makes specific proteins. These proteins affect inflammatory mediators that leads to symptom improvement. This process takes 6-8 hours.
Answered 12/10/2013
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