Can grapefruit seed extract lose potency if taken on and off and create antibiotic-resistant organisms?

Not an antibiotic: Grapefruit seed extract does not have any clinically proven antibiotic properties. Like many alternative medicines, it is used by the natural health movement based on anecdotal evidence, not by proven scientific methods. Google scholar CAM studies are of very low quality. Therefore given that there is no good evidence it can kill bacteria, it is unlikely to create antibiotic resistance.