I am on 25 mg of zoloft and 50 mg of wellbutrin (bupropion). would a glass of wine here or there be harmful?

Probably not: But would check first with the doctor ordering your medication.

It is recommended: that you do not use alcohol if you use wellbutrin or if you take zoloft. Didn't your doctor medically advise against it?

Yes, no alcohol: Alcohol is a poison that never did anybody any good, ever, so stay away from it. Given the medications you are taking, it would be unwise for you to take alcohol. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex, if you have sex.