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A member asked:
What is iga kappa monoclonal protein?
3 doctors weighed in across 2 answers
MGUS or....: We all have poly(many)clonal immunoglobulins (ig's) such as iga, igg, igm, ige, IgD that help fight infection. Another name of ig's is antibodies. A mono(one)clonal population of ig's is mgus -- monoclonal gammopathy of undetermined significance -- or related to a more significant problem. Mgus actually be multiple myeloma or be related to another disorder (eg cll, nhl).
Answered 1/12/2015
5.3k views
IgA paraprotein: An IgA kappa monoclonal protein represents a single clone of bone marrow cells that have reproduced in an aberrant fashion. If this is what is found on immunofixation then a hematologist should be consulted for further workup.
Answered 8/18/2019
5.3k views
Related Questions
A member asked:
Kappa/lambda FLC ratio high (2.75) w/ normal K(10.21mg/dl) & low L(3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow
5 doctors weighed in across 2 answers
A member asked:
Immunofixation, Serum FAH = Monoclonal IgG kappa immunoglobulin. Beta FAH = 10.5% Abnormal band, immunofixation to follow. I'm IgA deficient too. ??
A doctor has provided 1 answer
A member asked:
Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?
2 doctors weighed in across 2 answers
A member asked:
More info on serum immunofixation..no monoclonal proteins detected.a faint IgG labda cannot be ruled out.suggest repeat 6 mths.igg 841 IgA 251 IgM 44.
A doctor has provided 1 answer
People also searched for:
Just found out that I have an IgA kappa monoclonal protein in my blood stream?! what can cause this? I have hep c and one kidney, lost other in 2008
High IGA (7.09 g/l), and low IGG (3.05) and low IGM (.15). Beta1 globulin is high, beta2 and gamma are low. Protein Monoclonal band is detected type IGA at 8.5 g/l. FLC = high lambda at 33.4mg/l (normal kappa &ratio). Worried until I see hematologist?
I am 45 and male. Serum IgA at 472 mg/dl and an apparent polyclonal gammopathy IgA kappa/lambda typing appear increased. Serum free light chain: high kappa 35 mg/L, lambda normal 17.8 mg/L and a ratio of 1.97. Is this Myeloma? No M-protein found?
Free kappa light chain is high, FLC ratio is 2.205, no monoclonal gammopathy. IgA 389.43, lgM 125.95 and lgG 1771.02 H. Should we be worried? Thanks.
What is the significance of IGA Kappa Monoclonal in Beta? 36 y.o. with slightly elevated wbc (14-21k) for past year.
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