A member asked:

What is iga kappa monoclonal protein?

3 doctors weighed in across 2 answers
Dr. Michael Thompson answered

Specializes in Hematology and Oncology

MGUS or....: We all have poly(many)clonal immunoglobulins (ig's) such as iga, igg, igm, ige, IgD that help fight infection. Another name of ig's is antibodies. A mono(one)clonal population of ig's is mgus -- monoclonal gammopathy of undetermined significance -- or related to a more significant problem. Mgus actually be multiple myeloma or be related to another disorder (eg cll, nhl).

Answered 1/12/2015

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IgA paraprotein: An IgA kappa monoclonal protein represents a single clone of bone marrow cells that have reproduced in an aberrant fashion. If this is what is found on immunofixation then a hematologist should be consulted for further workup.

Answered 8/18/2019

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