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East Meadow, NY
A 24-year-old female asked:

I have mthfr 2 mutations, i had 3 miscarriages one 2nd trimeste loss chances of this causing them?

3 doctor answers3 doctors weighed in
Dr. Arthur Mandelin
Rheumatology 20 years experience
Maybe: The only way to know this would be to prove that the cause of the pregnancy loss was clotting which interrupted blood flow to the fetus. This can only be known by autopsy of the fetus. It does sound suspicious, and you may want to be sure you have been tested for all forms of excess blood coagulation. 2nd trimester loss is less consistent with a clot.
Dr. Su Fairchild
Integrative Medicine 24 years experience
Depends: Depends on cause of miscarriage. If due to clot, mthfr heterozygotes do not have an increased risk. Protein s deficiency, protein c deficiency, and anti thrombin deficiency if homozygous in the fetus can be a cause of miscarriage.
Dr. Liesa Harte
Family Medicine 29 years experience
MTHFR SNPs: Yes, methylation problems can definitely cause miscarriages and birth defects. Knowledge is powerful, though. Find a provider who understands how to evaluate and treat this. Have a look at www.mthfr.net there is a list of providers with extra training on MTHFR.

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Last updated May 24, 2014

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