If my thyroglobulin is 78. u/ml how sure can u be that i have hoshimoto thyroid disease? i

Not sure: Thyroglobulin is not used to diagnose hashimotos. You need the antibodies, especially thyroid peroxidase antibodies to make this diagnosis.

Antibodies?: Anti-thyroglobulin antibodies (ata) or tgab can be seen in patients with hashimoto thyroiditis or graves disease. So, you cannot be certain: however, symptoms of each disease are quite different. In one you are "hyper-metabolic" (too much hormone) and in the other you are "hypo-metabolic) (too little hormone). Your doctor can help you separate.