A member asked:

I experienced no fatigue after first dose of 10mg methotrexate. is it because i just started and it hasn't built up in my body, or maybe i won't at all?

7 doctors weighed in across 3 answers

Probably : Fatigue is one of the most common side effects. Most patients have pretty constant symptoms so it is possible you will not experience fatigue. It can but rarely do side effects accumulate with time.

Answered 2/18/2015

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Dr. Larry Greenbaum answered

Specializes in Internal Medicine - rheumatology

Maybe u won't at all: The majority of my patients on Methotrexate do not complain about fatigue.

Answered 6/28/2014

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Dr. Thomas Namey answered

Specializes in Rheumatology

You may not!: But take it by injection. Far fewer side effects and cheaper!

Answered 11/28/2017

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