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A 28-year-old female asked:

Why do u think my md still suspects sjogrens vs lupus(ana 1:640, negative lip biopsy, raynauds, fatigue, photosens, rashes, jt/muscle pain, sicca ?

2 doctor answers4 doctors weighed in
Dr. Ronald Krauser
A Verified Doctoranswered
Rheumatology 54 years experience
The clinical picture: It is often difficult to determine whether sjogrens is a primary diagnosis or secondary to other connective tissue disorders such as lupus. . The lip biopsy is not foolproof but if salivary glands present were all normal then i would suspect that lupus was primary and the sjogrens was secondary.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Ed Friedlander
Pathology 46 years experience
Nobody really knows what lupus really is or Sjogren's really is. They often run together. Rheumatology is a paradox -- there are more individual labs in this field, yet perhaps no other specialty ultimately comes down not to labs but to the clinician's history and physical exam and rapport with the patient. You have my best wishes as you work together toward a diagnosis.
Dec 6, 2012
Dr. Sheeja Francis
Rheumatology 22 years experience
Undifferentiated CTD: Clinical presenation can be classified as an undifferentiated connective tissue disease (uctd). Likely not primary sjogren's since lip biopsy (usually gold standard for diagnosis of sjogren's) was negative. Would recommend additional evaluation including specific antibodies such as dsdna and ena. Also would recommend rheumatology consult.
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Oct 4, 2016

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