What do i do to treat a mosquito bite to the eye lid when there's significant swelling?

Ice, time: Mosquito bites to the eyelid can be quite itchy and sometimes painful. Since the lid skin is loose (so the lid can move properly), any edema or inflammation can spread over a large area. Use ice to help it . Sometimes you might be helped with an oral antihistamine like Benadryl (diphenhydramine) or chlorpheneramine. It will go away with time.