Can quitting smokin cause severe akathisia/restlessness? i have been on seroquel for years and zoloft (sertraline) for one month now. just began to quit smoking.

Can raise bloodlevel: When you quit smoking the blood level of the psychotropics go up & they may give you the neurological side effects.

Probably not at all: Some medication levels change after stopping, because chemicals in tobacco can change your metabolism. Zoloft (sertraline) level may increase, so you may not need as much. But the change is not usually dramatic. Seroquel will probably stay the same - but monitor how you feel with your provider. More info at http://www.Merseycare.Nhs.Uk/library/what_we_do/clinical_services/public_health/smoking_interactions.Pdf.

Maybe: Zoloft (sertraline) and seroquel are substrates of 3a4, 2d6, and 2c19 liver enzymes. Nicotine is probably neither an inducer nor inhibitor of these cyp450 enzymes (altho it may speed up the metabolism of drugs processed by 1a2 and 2e1 enzymes). Thus your "akathisia" is probably just the result of losing the "calming" effects of the nicotine.