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A 33-year-old female asked:

can i take zyban (bupropion) and sertraline together? i have md and want to quit smoking. i am going off sertraline as i don't feel it is working. i'm in the uk

2 doctor answers5 doctors weighed in
Dr. Donald Jacobson
A Verified Doctor answered
A US doctor answered Learn more
Yes, the two are: Often prescribed together in doses not to exceed 300 mg per day. Do not stop her zoloft (sertraline) without contacting your treating physician. You may find that the zoloft (sertraline) suddenly starts working when the wellbutrin is added in. This is a common combination in which two antidepressants are used together to achieve remission from depression. In your case, you are using bupropion for a different purpose but you may be able to kill two birds with one stone by staying on both.Best wishes and congratulations on your decision to quit smoking.
Dr. Heidi Fowler
Psychiatry 25 years experience
Drug safety: Sertraline and bupropion are often prescribed safely in combination.

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Last updated Oct 21, 2018

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