I am 51. at 47 i had tia, dvt, pulmonary embolism, hole in heart. i am on warfarin and aggrenox. new white places in brain. should i be concerned?

Yes: Should close "hole in the heart". I do not know specifically what you mean for "hole in the heart". Each congenital septal defect has a name and unless you specify which is it I am unable to give you any advise but as a general rule, any septal defect can result in a paradoxical embolus. Meaning blood clots from the venous system ending up in the arterial system. Your cardiologist can reffer you.

Yes: Having had a TIA you are at risk for having more. Coumadin (warfarin) reduces the risk but doesn't eliminate it. If the hole in the heart is a cause for the emboli, can the hole be closed? Consult your cardiologist.

Yes: Atrial septal defects and patent foramen ovale are the most common (heart holes). The fact that you have a history of tias and dvt/pe should be a concern for a paradoxical embolus. You should see a cardiologist who should refer you to a structural interventional cardiologist or a minimally invasive cardiac surgeon to repair this defect.