6-8 months for beta: Alpha thalassemia major is generally fatal before birth, with just rare cases born alive. Beta thalassemia major babies look normal at birth because fetal hemoglobin doesn't need beta globulin. As fetal hemoglobin goes away and adult hemoglobin starts being made, the baby will feel the effects of his lack of beta globulin. Symptoms start after the first 6-8 months of life.
Answered 6/24/2014
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6 to 12 months: If not otherwise sick, symptoms will start to be seen as the bone marrow fails to recover from the normal anemia that occurs around 2 months of age.
Answered 2/17/2015
5.8k views
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