Probably not safe: Nattokinase has fibrinolytic activity which is a different mechanism than warfarin which is a vitamin k antagonist interfering with synthesis of prothombin and factor vii. The combination is likely synergistic. The product label clearly states they should not be used together and i don't doubt that the combination would increase the risk of pathological bleeding including intracranial hemorrhage.
Answered 12/4/2012
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