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A 24-year-old member asked:

is fibromyalgia genetic?

5 doctor answers11 doctors weighed in
Dr. Betty Keller
Rheumatology 35 years experience
Possibly: There is some evidence that there is a genetics may play a role in fibromyalgia.
Dr. Jay Rosenfeld
A Verified Doctoranswered
A US doctor answeredLearn more
Possibly: There has been some research that suggests that tendency to chronic pain and fibromyalgia may have some genetic basis however this question is far from clear. Most conditions are usually a combination of genetic as well as environmental factors which are complex.
Dr. Laurence Badgley
General Practice 53 years experience
I consider that the genetic relationships exist as the Joint Hypermobility Syndrome (JHS) aspect, which is highly associated with fibromyalgia. I discuss this on Quora.com.
Mar 9, 2013
Dr. Michael Rothman
Internal Medicine 35 years experience
Yes: Fibromyalgia is a multifactorial consequence of hormonal, immune system and nervous system dysfunction resulting from genetic predispositions and dietary and environmental insults. These factors impact your immune system and can lead to pain and inflammation. If affecting your joints-arthritis, if affecting your connective tissue and muscles - fibromyalgia.
Dr. Laurence Badgley
General Practice 53 years experience
Yes : #fibromyalgia has been proven to have genetic relationships. This medical information has mostly been discovered in england, where there are 32 clinics devoted to joint hypermobility syndrome (jhs). Most american doctors are ignorant of this information, see comment below. Joint hypermobility syndrome is an associated marker and has genetic relationships.
Dr. Laurence Badgley
General Practice 53 years experience
Provided original answer
A doctor at Heathtap.com, a Rheumatologist, commented that he has, "found no increased incidence of hypermobility in my scores of patients with FM".  His comment is not atypical.  In 1999, a study in England revealed that amongst Rheumatology referrals only  4.67% of persons with the joint hypermobility phenotype were being recognized, despite criteria for evaluating JHS.  A study reviewer stated, "hypermobility is under-medicalized!" (British Society of Rheumatology  members' Hypermobility Syndrome perception survey,  1999 [Grahame R, Bird H.  Rheumatology 40 (5): 559-69, 2001].  As early as 1966, it was stated, "another view is that isolated ligamentous laxity is a mild mesenchymal developmental disorder which lies at one end of a spectrum of heredofamilial connective issue disease with a fully-developed picture of Marfan's and Ehlers-Danlos at the other (Kirk JA, Ansell BM, and Bymster EG.  Ann Rheum Diseases 1967 26: 419-425. In 1993, a study tested an hypothesis that joint hypermobility is participant in the pain of fibromyalgia.  338 children between 9 and  15 were evaluated with findings that 13% had joint hypermobility and 6% had fibromyalgia per ACR criteria.  81% of the children with fibromyalgia had joint hypermobility.  40% of the children with joint hypermobility had fibromyalgia.  One conclusion was, "the study suggests that there is a strong association between joint hypermobility and fibromyalgia in school children (Buskila et al.  Joint Hypermobility in School Children.  Annals of Rheumatic Diseases.  Vol: 11, No. 1, pp39-42).  In 1998, a study in Spain compared 66 women with fibromyalgia to 70 women with other Rheumatologic  diseases.  The study found that 27% of women with fibromyalgia had joint hypermobility compared to 11.4 % of women with other Rheumatologic disorders (Acasuso-Diaz and Collantes-Estevez.  Joint Hypermobility in Paients with Fibomyalgia.  Arthritis  Care and Research,  Vol: 11, ( FitzCharles opined, in 2000, "there is increasing evidence that at least a sub-group of patients with soft tissue musculoskeletal pain, widespread pain, or fibromyalgia are hypermobile.  Clearly, hypermobility is not the only or the major factor in the development of widespread pain or fibromyalgia, but rather a contributing mechanism in some individuals" (FitzCharles M.  Is Hypermobility a Factor in Fibromyalgia?"  Journal of Rheumatology, Vol: 27. no.7, pp 1587-1589, 2000. A book devoted to the subject was published (Elsevier in 2010).  "Hypermobility, Fibromyalgia, and Chronic Pai n", edited by Professor Rodney Grahame; past editor of "Rheumatology", and held presidency of British Society for Rheumatology.   Somewhere in the midst of practicing medicine for 48 years, I discovered a truism about the practice of medicine follows:  "within the practice of medicine what is not looked for is rarely seen".
Jul 18, 2013
Dr. Laurence Badgley
General Practice 53 years experience
Provided original answer
The book "Hypermobility, Fibromyalgia, and Chronic Pain" is a seminal work, and a "must read" for any doctor interested in fibromyalgia.
Jul 18, 2013
Dr. Liesa Harte
Family Medicine 29 years experience
Fibromyalgia: Fibromyalgia is a syndrome with many components. Certain genetic SNPS can predispose someone to fibromyalgia, but I would not say that it is genetic.

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A member asked:

Are there some genetic reasons I get fibromyalgia off and on?

3 doctor answers6 doctors weighed in
Dr. K. Olson
Dr. K. Olsonanswered
Psychiatry 39 years experience
Possibly: There may be a genetic predisposition as there is clustering of cases in families (aggregation). Stress may activate it. It is more common in women, 9 to 1. If an identical twin has it there is 15% chance the other one will develop it as well. The inheritance likely involves many genes, typically those involving dopamine, serotonin, or norepinephrine.

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