A member asked:

How much does wife of 11 years stopping zoloft (sertraline) cold turkey have to do with her wsnting to end relationship?

4 doctors weighed in across 2 answers

Ending relationship?: Usually people takes zoloft (sertraline) for depression and anxiety. Stopping medications cold turkey can make someone depressed , anxious and irritable . Ending relationship it depends how satisfied someone was with this relationship?!

Answered 5/7/2016

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Dr. Heidi Fowler answered

Specializes in Psychiatry

The two issues: May or may not be related. Some people can develop SSRI discontinuation syndrome if they abruptly stop a medication like Zoloft. More likely to occur with large doses that have been taken over a long period of time. It can make one feel a bit like road kill for a few days. Also, premature discontinuation of an antidepressant can lead to return of depressive of symptoms.

Answered 11/8/2018

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