A member asked:

How to amitriptyline and vyvanse (lisdexamfetamine) interact?

6 doctors weighed in across 2 answers

Drug interaction: I'm assuming your doctor and pharmacist are aware you are taking both these medications. The combination can cause an increased release of norepinephrine. Report any rapid heartbeat, palpitations, or shortness of breath immediately to your physician and pharmacist. Avoid any other stimulants while taking this combination.

Answered 6/6/2020

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Dr. Heidi Fowler answered

Specializes in Psychiatry

Potentially - yes: Per Drugs.com , combining Vyvanse and amitryptyline can cause increase in blood pressure, fever, headache, or fast or irregular heartbeat. Make sure your prescribing providers are aware.

Answered 1/5/2020

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