A 40-year-old member asked:

How long will cymbalta (duloxetine) stay in the body?

1 doctor answer4 doctors weighed in
Dr. Mark Reynolds
Psychiatry 35 years experience
Well......: The half-life of Cymbalta (duloxetine) is about 12 hours. It takes about 5 half-lives for medication to essentially be cleared from your system. However, since some people metabolize the medication more slowly it would be safe to assume the medication would be gone from your system within five days.
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A 42-year-old member asked:

Will cymbalta (duloxetine) stay in my body long enough to taper itself?

2 doctor answers8 doctors weighed in
Dr. Samuel Miles
Psychiatry 49 years experience
Variable speed: When one stops taking a drug like cymbalta, (duloxetine) it will leave the body through metabolism and excretion. If it leaves the system too rapidly, a discontinuation syndrome may occur, including vertigo and flu like symptoms. The rate at which the drug leaves the system varies from person to person. So, i always recommend a taper instead of abrupt discontinuation when someone is taking a higher dose.
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Apr 19, 2018


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